WP03 – Data collection on European drug availability, pricing and policies

Objectives

  • To provide drug codification, using World Health Organization’s ATC system, with regular updates to both ClanWilliam Health (for use within SENATOR software, WP04) and to ClinInfo data management (WP10).
  • To assess baseline drug availability, pricing and reimbursement in each participating site.
  • To update drug availability, pricing and reimbursement in each participating site.
  • To identify the most suitable database of drug product files (using First Data Bank®) in each centre and to enable the mapping of drug – drug and drug – disease interactions for the SENATOR software.
  • To devise an approach for continual adaptation to drug availability and pricing for pan-European use of the SENATOR software.

Workpackage Description

The availability of drug compounds as well as brands, strengths, and packages available of the same compound varies across Europe. Most hospitals buy drugs through tenders which may over time change due to availability and older drugs going off licence. The WHO ATC code is the most widely used classification system for drugs in Europe which is important for drug utilisation and pharmacoeconomic analysis of the RCT.

The drug availability, prices and policies are time sensitive information which has to be updated and monitored continually in each country. Many countries have clinical guidelines on which drugs are recommended which may also change frequently. Each of the six clinical institutions has its own medication ordering system with underlying price lists. The SENATOR engine will use a process to identify the recommended drugs for different clinical scenarios. When this process is identified, the recommended drugs will be dynamic depending on new drugs and which cheaper alternatives come on the market.

At the first stage UoI and LUH will be involved in compiling the meta-data on compound names, strength, prices, and ATC codes. SDU, UoI, and LUH will also be responsible for the mapping of changes through the course of the project. Data will be provided by the six study centres (UCCUGENTSERMASNHSGINRCA, LUH) as part of the RCT (WP08). SDU, LUH, UoI, UCC and UEA will cooperate on the outcome evaluation of the trial. Lastly, SDU, UoI, UCC, and ClanWilliam will cooperate on the continual adaptation approach to ensure the sustainability of the SENATOR software.

WP Leader

Prof. Dr. Anna Birna Almarsdottir (UoI/SDU)
Prof. Stephen Byrne (UCC)

Participating Partners

University College Cork (UCC)
ClanWilliam Health Ltd, Dublin (ClanWilliam)
University of East Anglia (UEA)
Landspitali University Hospital Reykjavik (LUH)
University of Iceland (UoI)
University of Southern Denmark (SDU)